Trazodone for insomnia vs depression12/28/2023 ![]() ![]() Coase warned, “If you torture the data long enough, it will confess. Patients with major depressive disorder (MDD), both adult and pediatric, may experience worsening of their depression and/or the emergence of suicidal ideation. The risks and benefits of various prescription sleeping pills can differ. Coincidentally (although as skeptics, we do not believe in coincidence), the initial statistical team was changed when data were sold to the French pharmaceutical company applying for the marketing authorization in France. Trazodone is efficacious for the treatment of a broad array of depressive symptoms and is particularly useful for patients presenting with insomnia as one of. Prescription sleeping pills may help you fall asleep easier or stay asleep longer or both. Although he cited us,3 he overlooked the evidence we provided indicating that the Bacloville article4 was published without acknowledging major changes to the initial protocol, affecting the primary outcome. Thats the reason that physicians prescribe this medication primarily as a treatment for insomnia rather than a remedy for depression. Second, Dr Andrade should have warned readers that Bacloville’s results are most questionable, lacking robustness. Purpose: This was an observational, prospective, single-group, multicentre, international study aimed to describe the clinical response, functional impairment, and quality of life (QoL) of patients suffering from major depressive disorder (MDD) and in treatment with Trazodone Once-A-Day (TzOAD) monotherapy, over a 24-week period. To the Editor: Dr Andrade’s analysis of the Bacloville trial in a recent Clinical and Practical Psychopharmacology column, in which he concluded that “individualized treatment with high-dose baclofen (30-300 mg/d) may be a useful second-line approach in heavy drinkers” and that “baclofen may be particularly useful in patients with liver disease,” deserves comment.1įirst, Andrade failed to recall that the first pivotal trial of baclofen, ALPADIR (NCT01738282 320 patients, as with Bacloville), was negative (see Braillon et al2). Baclofen, a French Exception, Seriously Harms Alcohol Use Disorder Patients Without Benefit Clinical improvement, as assessed by a reduction of more than 60 in MADRS scale scores, was accompanied by evidence of the definitely beneficial effects of. Insomnia without depression: Because there’s so little supporting evidence, treatment guidelines by the AASM don’t recommend trazodone for the treatment of chronic insomnia. ![]()
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